What is GHRP-6?

GHRP-6 (Growth Hormone Releasing Peptide – 6) is a peptide hormone, basically a hexapeptide. It contains a chain made up of 6 amino acids. It is one of numerous man-made met-enkephalin analogs that incorporate unnatural D-amino acids. GHRP-6- is a non-pyrogenic and germ-free powder which is administered intramuscularly or subcutaneously. GHRP-6 is one of the true human growth hormone secretagogues (GHS).

A number of secretagogues (a name given to a substance which causes another substance to be secreted – in this case growth hormone) have been widely in use for their clinical activities and health promotion. GHRP-6 fuels secretion of growth hormone (GH) the same way as does the GH itself and provides similar actions on the muscle mass, joints, and skin. It has the potential to lessen or even undo several symptoms of deficiency of human growth hormone (hGH).

The legitimate and authorized use of hormone replacement therapy is a way of endorsing a longer and healthier life with better health outcomes. GHRP-6 is one of those which offer vigour and energy to the body. However, it is important to know that GHRP-6 is distinctive from growth hormone releasing peptide and does not have any action on the GHRH receptor, but it mainly acts at the HGH secretagogue receptor, which is known as the ghrelin receptor. Ghrelin is a powerful stimulator of the release of growth hormone from the anterior pituitary gland and is a known protector of neurons.

How Does GHRP-6 Boost HGH Levels?

GHRP-6 has a special role in boosting the levels of human growth hormone. This peptide acts at the hypothalamus and the pituitary in order to release Growth hormone (GH). It provides a signal to the body to initiate growth hormone (GH) secretion and its release, while on the other hand it inhibits Somatostatin, which is a hormone responsible for inhibition of Growth Hormone release.

GHRP-6 also enhances levels of hGH by reducing the influence of the somatostatin at the pituitary. Additionally, it has an action on somatotrophs (the pituitary cells) which encourages the discharge of GHRH (growth hormone releasing hormone) by increasing cAMP formation, which may further lead to the release of hGH from somatotroph stores.

An injection of GHRP-6 can raise the level of basal growth hormone to 4 times while the IGF-1 level remains boosted for seven days following its injection.
IGF-1 is the principal vehicle through which hGH affects its incredible, age-flouting attributes. High levels of IGF-1 move through the blood and enhance the metabolism rate and provide boosted energy levels for all types of physiological function. Additionally, IGF-1 works to stimulate the healthy growth of new cells within several organs and bones throughout the body.

Advantages Of GHRP-6 Over HGH
Research studies have demonstrated that stimulation of Growth Hormone by GHRP-6 offers a number of valuable effects, for example, it can increase the muscle mass, reduce body fat, and enhance the stamina and strength, thus it can make the best use of GH formation as well as secretion.

Human Growth Hormone (hGH) affects absolutely every aspect of the functions of our body. During childhood, it is hGH which controls the essential growth-linked activities. When we enter into adulthood, hGH still plays an important role, yet its production decreases with an increasing age. Here comes the role of GHRP-6. GHRP-6 works to facilitate the natural production of hGH by the body. When exogenous hGH is given, it can only replace the hormones produced by our bodies and help reverse the process of aging. On the other hand, GHRP-6 stimulates the production and release of natural hGH.

This ultimately means that there is no competition of natural hGH with the exogenous or synthetic one. This natural hGH then helps in restoring optimal levels of growth hormone in the body and endorses youthfulness and vitality of the body, which is often lost when growth hormone levels started to decline with age. GHRP-6 not only provides the liveliness and anti-aging effects of hGH, but also it helps keep the good health of the pituitary gland. Some of the other advantages of GHRP-6 are detailed below.

Benefits of GHRP-6 Helps to lose weight devoid of any strenuous exercises and dietMake your body stamina strong and improve level of energy Provides a healthier and faster metabolismHGH Peptides for Anti AgingImproves the elasticity of the skin so it looks smoother and youngerReduces of sagging and wrinkles of the skinImproves memory and enhances concentration Grows lustrous and heavier hairBrings back the sex drive and improve performanceEnhances body immunity Promotes deeper, longer sleep and improves the sleeping patterns. GHRH-6 dramatically enhances the formation of human growth hormone during the sleep cycle. This deep relaxing sleep and elevated production of HGH boosts the ability of the body to recover and revive from everyday life. The “pulsatile” release of growth hormone by GHRP-6 makes this peptide far better than the exogenous hGH. Also, using secretagogues like GHRP-6 is considered superior to that of synthetic hGH because via GHRP-6 there is a stimulation of natural GH release, without any unnecessary shutdown of the pituitary gland. Our pituitary gland is itself competent enough of secreting a great amount of GH.

Furthermore, GHRP-6 is an extremely effective anti-aging agent compared to hGH. It is a cost effective alternative to hGH. The expense of GHRP-6 is on average half of the expense of HGH replacement therapy because of the complex process needed to genetically engineer hGH. It appears that the potential treatment benefits provided by both GHRP-6 and hGH replacement therapy are the same but the ways via which these useful results are obtained, differ considerably.

Medical GHRP-6 Doses

GHRP-6 is not currently yet approved for medical use and is still in the phase of clinical trials. As such, there exist no officially determined prescription medical doses currently available.

GHRP-6 Doses for Performance and Physique

Enhancement It is both impractical and impossible to categorize GHRP-6 doses into the typical three tiers of users (beginner, intermediate, and advanced) due to the inherent nature of the type of substance and hormone. The saturation doses of GHRP-6 should elicit significant increases in HGH levels in the body in a pulsatile manner that is adequate enough to ensure any performance and physique enhancing goals desired by any individual. The difference in which goals might be more attainable than others is the frequency of dosing. GHRP-6 exhibits a varying half-life of approximately 15 – 60 minutes after injection, and will stimulate a large pulse of HGH from the pituitary gland that will last several hours but is most intense and achieves its peak at approximately 30 minutes. Therefore, in order to simulate higher and steadier blood plasma levels of HGH, it is necessary to administer GHRP-6 doses multiple times daily (depending on the user’s goals).

As a result, a general guideline for the purpose of achieving performance and physique enhancement is that of 100mcg administered three times per day. Each injection should be spaced evenly apart in order to achieve substantial HGH levels throughout the day due to the short half-life of GHRP-6 as well as the pulsatile manner of the HGH release that it causes. For greater results that would include more pronounced muscle gain and fat loss, more frequent injections would be required above the three times per day protocol. More details concerning the specific administration timing will be described shortly.

GHRP-6 doses can be administered subcutaneously (SQ) or intramuscularly (IM). There is not much difference between the two, with intramuscular seemingly resulting in a slightly quicker release from the injection site. The majority of individuals prefer to administer it subcutaneously for varying reasons, however.

It is important to understand that GHRP-6 doses on its own provides considerable HGH release from the pituitary gland, but is nowhere near as effective as the potential HGH release resultant from GHRP-6 combined with a GHRH such as Mod GRF 1-29 (CJC-1295 without DAC). Studies have demonstrated that the combination of GHRP-6 and a GHRH analogue such as Mod GRF 1-29 will generate a 77% increase in HGH output compared to GHRP-6 administration alone[8]. Other studies have gone so far as to explicitly state that GHRP-6 requires GHRH in order to stimulate maximal HGH stimulation as evidenced by the fact that in test subjects, the inclusion of a GHRH can increase HGH output by an additional 81 – 95%.

In general summary of the synergistic effect of both: a GHRH analogue (such as Mod GRF 1-29) will serve to initiate and carry forward the pulse of HGH from the pituitary gland, while the GHRP (such as GHRP-6) will serve to amplify this pulse.

Female GHRP-6 Doses

GHRP-6 is not a sex-specific hormone and therefore carries no androgenic effects that would present any issues. Therefore, female GHRP-6 doses are the exact same for all individuals, regardless of gender.

Proper Administration and Timing of GHRP-6 Doses

GHRP-6 is normally always manufactured as lyophilized (freeze-dried) powder contained in vials in amounts of 5mg. Some companies might manufacture amounts greater or lesser than 5mg per vial, but the standard is generally 5mg/vial. The lyophilized powder contained within the vial will need to be reconstituted with bacteriostatic water in order for it to be injected. After reconstitution, the solution must then be refrigerated in storage. If left in hot environments or in room temperature environments for extended periods of time, the protein structure will degrade and become ineffective. For reconstitution, users will typically mix 3ml of bacteriostatic water with the powder gently. However, users can and do frequently reconstitute the powder with less (or more) water which will yield different concentrations of GHRP-6. For example, reconstitution of 5mg of powder with 3ml of water will yield GHRP-6 doses of 166mcg per 0.1ml (or 10iu on an insulin syringe).

As with any GHRP or GHRH, administration of GHRP-6 doses should be done no sooner than 2 hours following the last meal containing carbohydrates or fats, and no sooner than 30 minutes prior to the next consumption of carbohydrates or fats. As evidenced by studies referenced in the introduction of this profile, the consumption of fats and carbohydrates will significantly blunt (but not eliminate) HGH release. HGH pulses will generally reach their peak by about 30 minutes following injection, after which it is then acceptable to consume a meal containing carbohydrates and fats.

As previously explained, multiple GHRP-6 doses are required throughout the day due to the pulsatile nature of the HGH release, and the administration of these doses are typically administered on average 3 times daily spaced evenly apart. More administrations are acceptable for greater effects on physique and performance, but it is advised that approximately 3 hours in between each injection is ensured so as to allow the pituitary gland to restore its storage of HGH. The most common protocol is as follows:

100mcg immediately upon waking up
100mcg immediately following the end of a workout
100mcg immediately before bed

It has been previously explained that some individuals will elect to administer GHRP-6 dosestwice daily, and some more than three times daily. Twice daily administration of at least 100mcg (typically upon awaking and before sleeping) will yield anti-aging and general health benefits. 3 times daily administration should yield general health benefits, fat loss, and muscle gain. 4 times daily or greater administration should provide more pronounced muscle gains and fat loss.

Finally, studies have determined that GHRP-6 administered alone stimulated an HGH release of 40 ng/ml in test subjects[10]. The same study determined that when combined with a GHRH (such as Mod GRF 1-29), the resultant HGH release was determined to be 130 ng/ml.