MOTS-c is a naturally occurring mitochondrial-derived peptide that acts as an “exercise mimetic” and metabolic regulator. Research, primarily in animal models, suggests it offers various benefits related to metabolism, physical performance, and healthy aging. Benefits of MOTS-C – Florida Anti-Aging Center

What Is MOTS‑c and How Does It Work?

MOTS‑c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid peptide encoded by mitochondrial DNA (mtDNA), not nuclear DNA like most hormones and peptides. It plays a central role in metabolic homeostasis, helping regulate glucose metabolism, fatty acid oxidation, and cellular stress response.

Key Benefits of MOTS-c

Improved Metabolic Function: MOTS-c is well-documented to enhance insulin sensitivity and glucose metabolism, helping the body manage blood sugar more effectively. It activates the AMPK pathway, a key enzyme that regulates cellular energy, and can prevent diet-induced obesity and fat accumulation in the liver.

Weight Management: By promoting the burning of fatty acids (fat oxidation) rather than fat storage, particularly in white and brown adipose tissues, MOTS-c may assist in weight management and the reduction of visceral fat.

Enhanced Physical Performance and Muscle Health: The peptide can improve muscle function, endurance, and recovery after activity. It helps prevent age- or immobilization-related muscle atrophy and increases muscle mass.

Anti-Aging Effects: MOTS-c levels naturally decline with age. Supplementation has shown potential in preclinical models to alleviate age-related metabolic disorders, cardiovascular impairment, and reduced exercise function, supporting healthy aging and potentially increasing lifespan.

Reduced Inflammation: Studies indicate that MOTS-c has anti-inflammatory properties, helping to suppress systemic inflammation by downregulating pro-inflammatory markers and increasing anti-inflammatory factors.

Cardiovascular and Bone Health: It may offer protective effects against cardiovascular diseases by attenuating vascular calcification and improving heart structure and function in certain conditions. It also promotes bone formation and inhibits bone resorption, which could help prevent osteoporosis.

➤ Recommended Dosage

→ Typical dose: 5–15 mg per week, split into 2–3 injections
→ Injection frequency: 2–3x weekly (e.g., Monday, Wednesday, Friday)
→ Cycle length: 2–4 weeks on, followed by 2–4 weeks off
→ Injection method: Subcutaneous (abdomen, thigh, or flank area)

Beginners often start with 5 mg/week and titrate up based on response and tolerance.

➤ Best Time to Inject MOTS‑c is most effective when used:

→ First thing in the morning on an empty stomach
→ 30–60 minutes before fasted cardio or training
→ On non-training days to maintain metabolic signaling

This mimics its natural production during fasting or calorie restriction and promotes better fat oxidation and glucose control.